Why is waste removal important to a cell

The Editors Articles signed by the editors were written in a collective effort. You might also be interested in. Visit our shop. Visit shop. Bachmair, A. Science , — Wong, C. PLoS Biol. Dougan, D. Download references. You can also search for this author in PubMed Google Scholar. Correspondence to Sascha Martens or Andreas Bachmair.

Reprints and Permissions. Martens, S. How cells coordinate waste removal through their major proteolytic pathways. Nat Cell Biol 17, — Download citation.

Published : 30 June Issue Date : July Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Simple practices can make some difference, such as exercise or calorie restriction.

But over the long haul all that really matters is progress in medicine: building new classes of therapy to repair and reverse the known root causes of aging. The sooner these treatments arrive, the more lives will be saved.

Find out how to help ». Autophagy consists of a collection of cellular housecleaning processes responsible for recycling damaged cellular components. It is known to relate to longevity, as demonstrated in numerous animals studies in which aging is slowed via genetic or metabolic manipulation, and in which autophagy is seen to take place more energetically.

This all seems logical, as aging is nothing more than an accumulation of unrepaired damage and the reactions to that damage, while autophagy seeks to minimize present damage before it causes more harm. Since we've already touched on of autophagy and its relationship to longevity today, as well as the prospects for developing therapies based on increased levels of autophagy , I thought I'd point out this popular science article on the topic:.

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Share Twit Share Email. Cellular recycling machinery for membrane protein disposal: Cells control the abundance of specific surface proteins and remove waste proteins by targeting them for uptake and disposal.

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